How does too much salt affect your brain?

excessive salt consumption affects your brain

Excessive salt consumption affects your brain

Cardiovascular diseases and high blood pressures are the clingy health disorders associated with high salt intake, and we are well-versed with that. But recent research studies have something more to highlight.

Coming back to how excessive salt consumption affects your brain, recent research studies highlight the rising concerns of high salt intake’s association with brain-related disorders. To list a few of these brain disorders are cerebrovascular diseases, cognitive impairment, and strokes. The endothelial cell linings of the cerebral blood vessels are thought to be responsible for these negative impacts.

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The endothelial cell lining of the blood vessels is responsible for vascular tone regulation. When you have a salt intake higher than your optimum level, it alters the normal functioning of these cells. There is evidence that reflects the rising concerns of epithelial dysfunction towards chronic illnesses. Perhaps, we still lack a confirmatory call about the alterations in brain activity caused by salt-induced endothelial dysfunction.

Research contributions of Costantino Iadecola  

Research contributions of Costantino Iadecola

Costantino from the Weill Cornell Medicine worked out research to highlight how excessive dietary salt is responsible for affecting our vital internal organs.

A group of mice was involved in this study and were subjected to human diet equivalent with a higher salt content for nearly twelve weeks. In the initial weeks itself, endothelial dysfunction coupled with a reduction in blood supply to the brain was noticeable. Further, cognitive decline was clear from the behavioral changes observed in rodents.

One of the prime outcomes of this research study was an increase in the gut’s TH17 white blood cell concentration. This increase further raised the levels of proinflammatory molecules, plasma interleukin-17 (IL-17).

Further, the research highlighted the molecular pathway through which these IL-17 increase contributed towards adverse cognitive effects in addition to the impact on cerebrovascular systems.

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On a final conclusion, the research infers that the adaptive immune response in the gut due to higher levels of IL-17 contributes towards neurovascular dysfunction and cognitive impairment.

Is it possible to reverse the adverse effects?

Is it possible to reverse the adverse effects

To hunt for the adverse effects reversal process, the mice group were subjected to a healthy diet with regulated salt levels. Interestingly, the mice were able to reverse the effects of vascular dysfunction as well as cognitive impairment with a healthy diet.

The drug, amino acid L-arginine reflects the same beneficiary effects on mice as that of the healthy diet.

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